“Murder At The Howard Johnson’s” takes place sometime in the 70’s in the same hotel but in three different hotel rooms. The first scene has Arlene Miller and her lover, Mitchell Lovell, trying to murder Arlene’s husband, Paul, who won’t give her a divorce. Mitchell also suffices as the Miller's dentist. They fail. The next scene has Arlene and Paul trying to murder the cheating Mitchell. They fail. In the final scene the two men are plotting to kill the fickle Arlene. No one dies in this laugh riot comedy but their attempts at murder are hysterical.